Publications

  • Shinya Abe, Moe Kagao, Takuma Asahi, Ryoma Kato, Shizue Tani-Ichi, Akihiro Shimba, Riki Ishibashi, Hitoshi Miyachi, Satsuki Kitano, Masaki Miyazaki, Hans-Reimer Rodewald, Fumiko Toyoshima, Koichi Ikuta
    The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow
    J Immunol. (2025) https://doi.org/10.1093/jimmun/vkaf001
  • Park Y, Matsumoto S, Ogata K, Ma B, Kanada R, Isaka Y, Arichi N, Liang X, Maki R, Kozasa T, Okuno Y, Ohno H, Ishihama Y, Toyoshima F
    Receptor-independent regulation of Gα13 by alpha-1-antitrypsin C-terminal peptides
    J Biol Chem. (2025) https://doi.org/10.1016/j.jbc.2024.108136
  • Ishibashi R, Maki R, Toyoshima F
    Gene targeting in adult organs using in vivo cleavable donor plasmids for CRISPR-Cas9 and CRISPR-Cas12a
    Sci Rep. (2024) https://doi.org/10.1038/s41598-024-57551-8
  • Satoshi Kozuki, Mio Kabata, Satoko Sakurai, Keiko Iwaisako, Tomomi Nishimura, Masakazu Toi, Takuya Yamamoto and Fumiko Toyoshima
    Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice
    Commun Biol. (2023) https://doi.org/10.1038/s42003-023-05614-3
  • Riki Ishibashi, Ritsuko Maki, Satsuki Kitano, Hitoshi Miyachi, Fumiko Toyoshima.
    Development of an in vivo cleavable donor plasmid for targeted transgene integration by CRISPR-Cas9 and CRISPR-Cas12a.
    Sci. Rep. (2022) https://doi.org/10.1038/s41598-022-22639-6
  • Ryo Ichijo, Koichiro Maki, Mio Kabata, Teruasa Murata, Arata Nagasaka, Seiichiro Ishihara, Hisashi Haga, Tetsuya Honda, Taiji Adachi, Takuya Yamamoto, Fumiko Toyoshima.
    Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin.
    Nature Aging. (2022) https://doi.org/10.1038/s43587-022-00244-6https://rdcu.be/cRpsh
  • Kozuki S, Sakurai S, Suzuki A, Yamamoto T, Toyoshima F.
    Delineation of biliary epithelial cell dynamics in maternal liver during pregnancy.
    Genes Cells. (2021) https://DOI: 10.1111/gtc.12918.
  • Oda Y., Takahashi C., Harada S., Nakamura S., Sun D., Kiso K., Urata Y., Miyachi H., Fujiyoshi Y., Honigmann A., Uchida S., Ishihama Y. and Toyoshima F.
    Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation.
    Sci. Adv. 7, 47 (2021) https://DOI: 10.1126/sciadv.abj6895
  • Ichijo R., Kabata M., Kidoya H., Muramatsu F., Ishibashi R. Abe K., Tsutsui K., Kubo H., Iizuka Y., Kitano S., Miyachi H., Kubota Y., Fujiwara H., Sada A., Yamamoto T. and Toyoshima F.
    Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs.
    Sci. Adv. 7, 7 (2021) https://DOI: 10.1126/sciadv.abd2575
  • Ishibashi R., Abe K., Ido N., Kitano S., Miyachi H., and Toyoshima F.
    Genome editing with the donor plasmid equipped with synthetic crRNA-target sequence.
    Sci. Rep. 10, 14120 (2020) https://doi.org/10.1038/s41598-020-70804-6
  • Murata, T., Honda, T., Egawa, G., Yamamoto, Y., Ichijo, R., Toyoshima, F., Dainichi, T. and Kabashima, K.
    Transient elevation of cytoplasmic calcium ion concentration at a single cell level precedes morphological changes of epidermal keratinocytes during cornification.
    Sci. Rep. 8, 6610 (2018) https://doi.org/10.1038/s41598-018-24899-7
  • Ichijo, R., Kobayashi, H., Yoneda, S., Iizuka, Y., Kubo, H., Matsumura, S., Kitano, S., Miyachi, H., Honda, T. and Toyoshima, F.
    Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration.
    Nat. Commun. 8, 508 (2017) https://doi.org/10.1038/s41467-017-00433-7
  • Fukuhara, M., Ma, Y., Nagasawa, K. and Toyoshima, F.
    A G-quadruplex structure at the 5' end of the H19 coding region regulates H19 transcription.
    Sci. Rep. 8, 45815 (2017) https://doi.org/10.1038/srep45815
  • Ikeda, M. and Toyoshima, F.
    Dormant pluripotent cells emerge during neural differentiation of embryonic stem cells in a FoxO3-dependent manner.
    Mol. Cell. Biol. 37, e00417-16 (2017) https://doi.org/10.1128/MCB.00417-16
  • Ichijo, R., Iizuka, Y., Kubo, H. and Toyoshima, F.
    Essential roles of Tbx3 in embryonic skin development during epidermal stratification.
    Gene Cells 22, 284-292 (2017) https://doi.org/10.1111/gtc.12476
  • Matsumura, S., Kojidani, T., Kamioka, Y., Uchida, S., Haraguchi, T., Kimura, A. and Toyoshima, F.
    Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1.
    Nat. Commun. 7, 11858 (2016) https://doi.org/10.1038/ncomms11858
  • Ishibashi, R., Kozuki, S., Kamakura, S., Sumimoto, H. and Toyoshima, F.
    c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Differentiation.
    J. Biol. Chem. 291, 3333-3345 (2016) https://doi.org/10.1074/jbc.M115.679563
  • Hanafusa, H, Kedashiro, S., Tezuka M., Funatsu, M., Usami, S., Toyoshima, F. and Matsumoto, K.
    PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.
    Nat. Cell Biol. (2015) https://doi.org/10.1038/ncb3204
  • Iwano, S., Satou, A., Matsumura, S., Sugiyama, N., Ishihama, Y. and Toyoshima, F.
    PCTK1 regulates integrin-dependent spindle orientation via PKA regulatory subunit KAP0 and myosin X.
    Mol. Cell. Biol. 35, 1197-1208 (2015) https://doi.org/10.1128/MCB.01017-14
  • Hamasaki, M., Matsumura, S., Satou, A., Takahashi, C., Oda, Y., Higashiura, C., Ishihama, Y. and Toyoshima, F.
    Pregnenolone functions in centriole cohesion during mitosis.
    Chem. Biol. 21, 1707-1721 (2014) https://doi.org/10.1016/j.chembiol.2014.11.005
  • Ikawa, K.,Satou, A., Fukuhara, A., Matsumura, S., Sugiyama, N., Goto, H., Fukuda, M.,Inagaki, M., Ishihama, Y. and Toyoshima, F.
    Inhibition of endocytic vesicle fusion by Plk1-mediated phosphorylation of vimentin during mitosis.
    Cell Cycle 13, 126-137 (2014) https://doi.org/10.4161/cc.26866
  • Matsumura, S., Hamasaki, M., Yamamoto, T., Ebisuya, M., Sato, M., Nishida, E. and Toyoshima, F.
    ABL1 regulates spindle orientation in adherent cells and mammalian skin.
    Nat. Commun. 3, 626 (2012) https://doi.org/10.1038/ncomms1634
  • Matsumura, S. and Toyoshima, F.
    ABL1 joins the cadre of spindle orientation machinery.
    Cell Struct. Funct. 37, 81-87 (2012) https://doi.org/10.1247/csf.12011
  • Mitsushima, M., Aoki, K., Ebisuya, M., Matsumura, S., Yamamoto, T., Matsuda, M., Toyoshima, F. and Nishida, E.
    Revolving movement of a dynamic cluster of actin filaments during mitosis.
    J Cell Biol. 191, 453-462　(2010) https://doi.org/10.1083/jcb.201007136
  • Mitsushima, M., Toyoshima, F. and Nishida, E.
    Dual role of Cdc42 in spindle orientation control in adherent cells.
    Mol. Cell. Biol. 29, 2816-2827 (2009) https://doi.org/10.1128/MCB.01713-08
  • Toyoshima, F., Matsumura, S., Morimoto, H., Mitsushima, M. and Nishida, E.
    PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells.
    Dev. Cell 13, 796-811 (2007) https://doi.org/10.1016/j.devcel.2007.10.014
  • Toyoshima, F. and Nishida, E.
    Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner.
    EMBO J. 26, 1487-1498 (2007) https://doi.org/10.1038/sj.emboj.7601599
  • Toyoshima, F. and Nishida, E.
    Spindle orientation in animal cell mitosis: roles of integrin in the control of spindle axis.
    J. Cell Physiol. 213: 407-411 (2007) https://doi.org/10.1002/jcp.21227
  • Matsumura, S., Toyoshima, F. and Nishida, E.
    Polo-like Kinase 1 Facilitates Chromosome Alignment during Prometaphase through BubR1.
    J. Biol. Chem. 282: 15217-15227 (2007) https://doi.org/10.1074/jbc.M611053200
  • Nakajima, H., Toyoshima-Morimoto, F., Taniguchi, E. and Nishida, E.
    Identification of a consensus motif for Plk1 (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.
    J. Biol. Chem. 278, 25277-25280 (2003) https://doi.org/10.1074/jbc.C300126200
  • Toyoshima-Morimoto, F., Taniguchi, E. and Nishida, E.
    Plk1 promotes nuclear translocation of human Cdc25C during prophase.
    EMBO Reports 3, 341-348 (2002) https://doi.org/10.1093/embo-reports/kvf069
  • Taniguchi, E., Toyoshima-Morimoto, F. and Nishida, E.
    Nuclear translocation of Plk1 mediated by its bipartite nuclear localization signal.
    J. Biol. Chem. 277, 48884-48888 (2002) https://doi.org/10.1074/jbc.M206307200
  • Toyoshima-Morimoto, F., Taniguchi, E., Shinya, N., Iwamatsu, A. and Nishida, E.
    Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase.
    Nature 410, 215-220 (2001) https://doi.org/10.1038/35065617
  • Toyoshima, F., Moriguchi, T., Wada, A., Fukuda, M. and Nishida, E.
    Nuclear export of cyclin B1 and its possible role in the DNA damage G2 checkpoint.
    EMBO J. 17, 2728-2735 (1998) https://doi.org/10.1093/emboj/17.10.2728
  • Toyoshima, F., Moriguchi, T. and Nishida, E.
    Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases.
    J. Cell Biol. 139, 1005-1015 (1997) https://doi.org/10.1083/jcb.139.4.1005
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